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DeCS
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Descriptor English:
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Complement C1q
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Descriptor Spanish:
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complemento C1q
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Descriptor Portuguese:
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Complemento C1q
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Synonyms English:
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C1q Complement
C1q, Complement
Complement 1q
Complement Component 1q
Complement, C1q
Component 1q, Complement
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Tree Number:
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D12.776.124.486.274.050.270
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Definition English:
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A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. |
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Pharmacological Action:
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Immunologic Factors
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History Note English:
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2006 (1990)
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Allowable Qualifiers English:
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Record Number:
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24573
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Unique Identifier:
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D015922
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Occurrence in VHL:
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Similar:
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DeCS
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